Translocation of IRS-1 to Cytosol Attenuates Insulin-Stimulated Glucose Transport without Affecting PI3-Kinase Activity~!2010-03-23~!2010-05-10~!2010-06-18~!
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چکیده
منابع مشابه
Translocation of IRS-1 to Cytosol Attenuates Insulin-Stimulated Glucose Transport without Affecting PI3-Kinase Activity
IRS-1 is a major substrate for insulin receptor tyrosine kinase. It is reported that intracellular translocation of serine-phosphorylated IRS-1 from low density microsome (LDM) fraction to cytosol attenuates its ability to transmit insulin signaling to the downstream molecules. In this study, we examined which insulin signal and action were affected by translocation of IRS-1 in 3T3-L1 adipocyte...
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Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and phosphatidylinositol 3-kinase (PI3-kinase), in linking the insulin receptor to glucose uptake; IRS-1 knockout mice are insulin resistant, and pharmacological inhibitors of PI3-kinase block insulin-stimulated glucose uptake. To investigate the role of PI3-kinase and IRS-1 in ...
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ژورنال
عنوان ژورنال: The Open Diabetes Journal
سال: 2010
ISSN: 1876-5246
DOI: 10.2174/1876524601003010014